Yes, it is highly encouraged in the treatment of male pattern hair loss to use a DHT blocker (such as Finasteride or Dutasteride) both topically as well as by mouth. While a DHT blocker taken orally helps lower the circulating DHT levels in the blood, using a DHT blocker topically in addition will lower the local level DHT on the scalp. Both topicals and pills containing DHT blockers can be used independently, however they are much more effective in combination.